Promotion-chasing Brentford take on Preston North End at Griffin Park in midweek action from the Sky Bet Championship.
Manchester City host Eddie Howe's Bournemouth at the Etihad Stadium, with the visitors fighting for points as they look to escape relegation.
Action from the Premier League as Newcastle United and Tottenham meet at St James' Park.
Mikel Arteta's Arsenal take on Premier League champions Liverpool at the Emirates Stadium in a big midweek clash from the top flight.
Two sides at opposite ends of the table meet as Leeds United host Barnsley at Elland Road in the Sky Bet Championship.
Everton face Aston Villa at Goodison Park in the Premier League. Villa need three points here as they continue to fight relegation.
Leicester City - in a battle to finish in the top four - play host to Sheffield United at the King Power Stadium in the Premier League.
Action from the Premier League as Crystal Palace host Manchester United at Selhurst Park.
Southampon and Brighton face-off in the Premier League at St Mary's Stadium.
Huddersfield Town welcome West Bromwich Albion to the John Smith's Stadium in the Sky Bet Championship.
West Ham United face Watford at the London Stadium in the Premier League in a relegation six-pointer. The Hammers won the reverse contest 3-1.