Millwall take on Birmingham City at The Den in the Sky Bet Championship. The sides shared the spoils in a 1-1 draw when they met earlier on in the season.
Middlesbrough take on Leeds United at the Riverside Stadium in the Sky Bet Championship.
Manchester City travel to the Santiago Bernabeu to take on Real Madrid in the first leg of their UEFA Champions League Round of 16 match.
Lyon and Juventus meet in the UEFA Champions League at Parc Olympique Lyonnais as they play their Round of 16 first leg tie.
Relegation-battling Norwich City face a tough test as they welcome top four-chasing Leicester City to Carrow Road in Friday Night Football from the Premier League.
Coventry City take on Sunderland at the St Andrew's Trillion Trophy Stadium in the Sky Bet Championship. A last-minute strike saw the Black Cats win 2-1 earlier in the season.
Brighton host rivals Crystal Palace at the AMEX Stadium as they meet in the Premier League.
Hull City welcome Marcelo Bielsa's Leeds United to the KCOM Stadium in the Sky Bet Championship. The Whites were 2-0 winners when the sides met earlier in the season.
Nigel Pearson's Watford welcome title-chasing Liverpool to Vicarage Road in the Premier League. A Mohamed Salah brace was enough to see the Reds over the lines in the reverse game.
Carlo Ancelotti's Everton take on Manchester United at Goodison Park in the Premier League. The sides shared the spoils in a 1-1 draw in the reverse fixture.